What do we actually know about people’s perceptions of COVID-19 and the vaccine in African countries? Upinion and Mercy Corps’ Crisis Analytics team decided to talk to the people themselves, and conducted an online conversation with 1862 individuals from Mali and Burkina Faso, and to a lesser extent Niger, in the winter and spring 2021/2022. It turns out that the majority of urban residents of Mali, Burkina Faso, and Niger, do plan on taking a COVID-19 vaccine, if it would become available to them.